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 ::: Publications
   
   
  • Diana Di Liberto, Massimo Locati, Nadia Caccamo, Annunciata Vecchi, Serena Meraviglia, Alfredo Salerno, Guido Sireci, Manuela Nebuloni, Neus Caceres, Pere-Joan Cardona, Francesco Dieli and Alberto Mantovani Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation and antimicrobial resistance in Mycobacterium tuberculosis infection. In press on Journal of Experimental Medicine.
  • Willem A Hanekom, Hazel M Dockrell, Tom H. M Ottenhoff, T. Mark Doherty, Helen Fletcher, Helen McShane, Frank F Weichold, Dan F Hoft, Shreemanta K Parida, and Uli J Fruth Immunological Outcomes of New Tuberculosis Vaccine Trials: WHO Panel Recommendation. PLoS Med. 2008 July; 5(7): e145. Published online 2008 July 1.
  • Caputo A, Brocca-Cofano E, Castaldello A, Voltan R, Gavioli R, Srivastava IK, Barnett SW, Cafaro A, Ensoli B. Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 DeltaV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin.Vaccine. 2008 Feb 26;26(9):1214-27.
  • Alberto Mantovani, Cecilia Garlanda, Andrea Doni, Barbara Bottazzi Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3. Received: 1 August 2007 / Accepted: 2 August 2007 / Published online: 9 September 2007 # Springer Science + Business Media, LLC 2007. J Clin Immunol (2008) 28:1–13 DOI 10.1007/s10875-007-9126-7.
  • Christine Sadorge, Anna Ndiaye, Nathalie Beveridge, Schale Frazer, Rafaela Giemza, Nathalie Jolly, Julie Johnson, Helen Liddy, Catherine A. Cosgrove, Paola Allavena, Alberto Mantovani, Stéphane Béchet, Annick Fontaine-Thompson, George E. Griffin, Francis Dupont, Philippe J. Sansonetti and David J.M. Lewis. “Phase 1 clinical trial of live attenuated Shigella dysenteriae type-1 ΔicsA Δent Δfep ΔstxA: HgR oral vaccine SC599 in healthy human adult volunteers”. 2007 Vaccine, in press.
  • Kirchhoff D, Frentsch M, Leclerk P, Bumann D, Rausch S, Hartmann S, Thiel A, Scheffold A. Identification and isolation of murine antigen-reactive T cells according to CD154 expression. Eur. J. Immunol. 2007; 37: 2370-2377.
  • Palazzo R, Spensieri F, Massari M, Fedele G, Frasca L, Carrara S, Goletti D, Ausiello CM. In-house bulk and single cell antigen-specific whole blood Interferon-gamma assays for surveillance of M. tuberculosis infection. Clin Vaccine Immunol. 2007.
  • Tempesta M, Camero M, Bellacicco AL, Tarsitano E, Lorusso A, Martella V, Decaro N, Del Giudice G, Cassone A, Quaranta A, Buonavoglia C Links Caprine herpesvirus 1 vaccine with the LTK63 mutant as a mucosal adjuvant induces strong protection against genital infection in goats.. Vaccine. 2007;25(46):7927-30.
  • Lavelle, E., Leavy, O. and Mills, K.H.G. (2007) Modified Bacterial toxins. In: Vaccine Adjuvants: Immunological and Clinical Principles. Ed. D. Harn and C.J Hackett. Humana Press. pp 113-155.
  • Lycke N. Mechanisms of adjuvant action. In: Vaccine Adjuvants and Delivery Systems, Ed. Singh Wiley & Sons, 2007 New Jersey, USA. pp 53-79.
  • Tritto E. Muzzi A., Pesce I, Monaci E, Nuti S, Galli G, Wack A, Rappuoli R, Hussell T, De Gregorio E. The acquired immune response to the mucosal adjuvant LTK63 imprints the mouse lung with a protective signature. J Immunol. 2007;179(8):5346-57
  • Andersen CS, Dietrich J, Agger EM, Lycke NY, Lövgren K, Andersen P. The combined CTA1-DD/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosis. Infect Immun. 2007;75(1):408-16.
  • Fedele G, Celestino I, Spensieri F, Frasca L, Nasso M, Watanabe M, Remoli ME, Coccia EM, Altieri F, Ausiello CM. Lipooligosaccharide from Bordetella pertussis induces mature human monocyte-derived dendritic cells and drives a Th2 biased response. Microbes Infect. 2007 9(7):855-63.
  • Kursar M, Jänner N, Pfeffer K, Brinkmann V, Kaufmann SH, Mittrücker HW. Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes. Eur J Immunol. 2007.
  • Mittrücker HW, Steinhoff U, Köhler A, Krause M, Lazar D, Mex P, Miekley D, Kaufmann SH Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosi. Proc Natl Acad Sci U S A. 2007 24;104(30):12434-9
  • Garlanda C, Di Liberto D, Vecchi A, La Manna MP, Buracchi C, Caccamo N, Salerno A, Dieli F, Mantovani A. Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling. J Immunol. 2007 Sep 1;179(5):3119-25.
  • Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A, Sallusto F, Napolitani G. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol. 2007 Jun;8(6):639-46. Epub 2007 May 7.
  • Macagno A, Napolitani G, Lanzavecchia A, Sallusto F. Related Articles Duration, combination and timing: the signal integration model of dendritic cell activation. Trends Immunol. 2007 May;28(5):227-33. Epub 2007 Apr 2.
  • Pido-Lopez J, Whittall T, Wang Y, Bergmeier LA, Babaahmady K, Singh M, Lehner T. Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4(+) T cells and dendritic cells.J Immunol. 2007; 178(3):1671-9
  • Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Orefici G, Fattorini L, Cassone A. The Ag85B protein of Mycobacterium tubercolosis may turn a protective immune response induced by AG85B-DNA vaccine into a potent but non-protective Th immune response in mice. Cell Microbiol.2007.
  • Cosmi L, Maggi L, Santarlasci V, Liotta F, Frosali F, Angeli R, Mazzetti M, Vultaggio A, Matucci A, Maggi E, Romagnani S,Annunziato F. Detection by Flow Cytometry of ESAT-6- and PPD Specific Circulating CD4+T Lymphocytes as a Diagnostic Tool for Tubercolosis. Int Arch Allergy Immunol. 2007; 143(1):1-9. Epub 2006 Dec 22.
  • Sheshko, V., Hejnova, J., Rehakova, Z., Sinkora, J., Faldyna, M., Alexa, P., Felsberg, J., Nemcova, R., Bomba, A. and P. Sebo*. HlyA- knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets. FEMS Imm. Med. Microbiol(2006) 47, 257-266.
  • Bergqvist P, Gärdby E, Stensson A, Bemark M, Lycke NY. Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers. J Immunol. 2006;177(11):7772-83
  • Helgeby A, Robson NC, Donachie AM, Beackock-Sharp H, Lövgren K, Schön K,Mowat A, Lycke NY. The combined CTA1-DD/ISCOM adjuvant vector promotes priming of mucosal and systemic immunity to incorporated antigens by specific targeting of B cells. J Immunol. 2006 ;176(6):3697-706.
  • Pardini M, Giannoni F, Palma C, Iona E, Cafaro A, Brunori L, Rinaldi M, Fazio VM, Laguardia ME, Carbonella DC, Magnani M, Ensoli B, Fattorini L, Cassone A. Immune response and protection by DNA vaccines expressing antigen 85B of Mycobacterium tubercolosis. FEMS Microbiol Lett. 2006 sep;262(2):210-5
  • Falcone V, Mihm D, Neumann-Haefelin D, Costa C, Nguyen T, Pozzi G, Ricci S. Systemic and mucosal immunity to respiratory syncytial virus induced by recombinant Streptococcus gordonii surface-displaying a domain of viral glycoprotein G.FEMS Immunol Med Microbiol. 2006; 48(1):116-22.
  • Hejnova J, Pages D, Rusniok C, Glaser P, Sebo P, Buchrieser C. Specific Regions of Genome Plasticity and Genetic Diversity of the commensal E. coli A0 34/86. 2006. Int J Med Microbiol. Oct 13 [Epub ahead of print].
  • Kaufmann SH.E., Baumann S., Nasser Eddine, A. Exploiting Immunology and Molecular Genetics for Rational Vaccine Design against Tuberculosis. 2006. Int J Tuberc Lung Dis.;10(10):1068-79.
  • Caccamo N, Sireci G, Meraviglia S, Dieli F, Ivanyi J and Salerno A. Gamma-delta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur. J. Immunol. 2006. 36: 2681-2690.
  • Ciabattini A., Cuppone A.M., Pulimeno R., Iannelli F., Pozzi G., Medaglini D. Stimulation of human monocytes with the Gram-positive vaccine vector Streptococcus gordonii. 2006. Clinical and Vaccine Immunology, 13: 1037-1043.
  • Whittall T, Wang Y, Younson J, Kelly C, Bergmeier L, Peters B, Singh M, Lehner T. Interaction between the CCR5 chemokine receptors and microbial HSP70. 2006. Eur J Immunol. 36: 2304-2314.
  • Dietrich J., Andersen C., Rappuoli R., Doherty T. M, Jensen C.G. and Andersen P. Mucosal administration of Ag85B-ESAT-6 protects against infection with M. tuberculosis and boost prior BCG immunity. 2006. Accepted by J Immunology.
  • Baumann S, Eddine AN, Kaufmann SH. Progress in tuberculosis vaccine development. 2006. Curr Opin Immunol. 18(4):438-48.
  • Cosgrove CA, Castello-Branco LR, Hussell T, Sexton A, Giemza R,Phillips R, Williams A, Griffin GE, Dougan G, Lewis DJ. Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine. 2006. Infect Immun 74:2449-52.
  • Azzurri A, Kanaujia GV, Sow OY, Bah B, Diallo A, Del Prete G, Gennaro ML. Serological markers of pulmonary tuberculosis and of response to anti-tuberculosis treatment in a patient population in Guinée. 2006. Int. J. Immunopathol. Pharmacol. 19:797-806.
  • Medaglini D., Ciabattini A., Cuppone A.M., Costa C., Ricci S., Costalonga M. and Pozzi G. In vivo activation of naive CD4+ T cells in nasal mucosa - associated lymphoid tissue following intranasal immunization with recombinant Streptococcus Gordonii. 2006. Infection and Immunity 74 (5).
  • Azzurri A, Sow OY, Amedei A, Bah B, Diallo S, Peri G, Benagiano M, D'Elios MM, Mantovani A, Del Prete G. IFN-gamma-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection. Microbes Infect. 2005 Jan;7(1):1-8
  • Esther Tamayo, Ramón Merino, Jovanna González-Rojas, Regina Marquina, Inés Santiuste, José Antonio Amado, Rino Rappuoli, Giuseppe Del Giudice and Jesús Merino. The Escherichia coli heat-labile enterotoxin induces apoptosis of immature lymphocytes in vivo via a glucocorticoid-dependent pathway. 2005. European Journal Immunology. 2005. Eur J Immunol. 35:3505-15.
  • Huo Z, Sinha R, McNeela EA, Borrow R, Giemza R, Cosgrove C, Heath PT, Mills KH, Rappuoli R, Griffin GE, Lewis DJ. Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal immunoglobulin A in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with chitosan. 2005. Infect Immun., 73(12):8256-65.
  • Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. 2005. Nat Immunol., 6(8):769-76.
  • Frentsch M, Arbach O, Kirchhoff D, Moewes B, Worm M, Rothe M, Scheffold A,Thiel A. Direct access to CD4(+) T cells specific for defined antigens according to CD154 expression. 2005. Nat Med., 11(10):1118-24.
  • Rimoldi M, Chieppa M, Larghi P, Vulcano M, Allavena P, Rescigno M. Monocyte-derived dendritic cells activated by bacteria or bybacteria-stimulated epithelial cells are functionally different. 2005. Blood, 106(8):2818-26.
  • Corradin G., Del Giudice G. Novel Adjuvants for Vaccines. 2005. Curr. Med. Chem. – Anti-Inflammatory & Anti-Allergy Agents, 4.
  • Rimoldi M, Chieppa M, Salucci V, Avogadri F, Sonzogni A, Sampietro GM, Nespoli A, Viale G, Allavena P, Rescigno M. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. 2005. Nat Immunol., 6(5):507-14.
  • Wang Y, T Whittall, E McGowan, J Younson, C Kelly, LA Bergmeier, M Singh and T Lehner. Identification Of Stimulating And Inhibitory Epitopes Within The HSP70 Molecule Which Modulate Cytokine Production And Maturation Of Dendritic Cells. 2005. J. Immunol., 174:3306-3316.
  • Corradin G. et al. Medicinal application of long synthetic peptide technology. 2004. Expert Opin. Biol. Ther. 4(10).
  • Eriksson. A , K Schön and N. Lycke. The cholera toxin derived CTA1-DD vaccine adjuvant administered intranasally is safe, does not accumulate in the nervous tissues, and effectively promotes a balanced Th1- and Th2-type of response. 2004. The Journal of Immunology, 173:3310-3319.
  • F. Dieli, N.Caccamo, S. Meraviglia, J. Ivanyi, G. Sireci, C. T. Bonanno, V. Ferlazzo, C. La Mendola and A. Salerno. Reciprocal stimulation of gamma-delta T cells and dendritic cells during the anti-mycobacterial immune response. 2004. Eur. J. Immunol 34: 3227-3235.
  • Garlanda C, Riva F, Polentarutti N, Buracchi C, Sironi M, De Bortoli M, Muzio M, Bergottini R, Scanziani E, Vecchi A, Hirsch E, Mantovani A. Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. 2004.  Proc Natl Acad Sci U S A 101(10):3522-6.
 
 
 
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